Article
A Buthus martensii Karsch scorpion sting targets Nav1.7 in mice and mimics a phenotype of human chronic pain.
Pain - 1 Feb 2022
Lu Wuguang, Cheng Xiaoyang, Chen Jiao, Wang Mingyuan, Chen Yonggen, Liu Jinman, Sang Ming, Zhao Ningwei, Yan Huaijiang, Cheng Xiaolan, Zhou Qian, Ye Juan, Wang Jin, Xu Erjin, Tang Zongxiang, Zhou Xi, Rong Mingqiang, Nilsen Erik A, Dib-Hajj Sulayman D, Waxman Stephen G, Yu Ye, Cao Peng
Abstract excerpt
ABSTRACT: Gain-of-function and loss-of-function mutations in Nav1.7 cause chronic pain and pain insensitivity, respectively. The preferential expression of Nav1.7 in the peripheral nervous system and its role in human pain signaling make Nav1.7 a promising target for next-generation pain therapeu...
Topics
- Animals
- Chronic Pain
- Humans
- Mice
- Phenotype
- Scorpion Stings
- Scorpion Venoms
- Scorpions