Article
Pronociceptive effects of nociceptin/orphanin FQ (13-17) at peripheral and spinal level in mice.
The Journal of pharmacology and experimental therapeutics - 1 Oct 2001
Inoue M, Matsunaga S, Rashid M H, Yoshida A, Mizuno K, Sakurada T, Takeshima H, Ueda H
Abstract excerpt
The heptadecapeptide nociceptin/orphanin FQ (N/OFQ) is reported to be metabolized by aminopeptidase N and endopeptidase 24.15. In the present study, N/OFQ C-terminal fragments elicited nociceptive responses in the peripheral nociceptors and in the spinal cord, whereas N-terminal fragments had no significant nociception. The nociceptive effect of N/OFQ (13-17) was most potent and remained unchanged in N/OFQ...
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