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A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathways

25 Jun 2025

Abstract excerpt

Neuroinflammation, defined as the inflammatory response in the brain or spinal cord, plays a pivotal role in multiple neurodegenerative conditions including Parkinson's and Alzheimer's diseases. Transient receptor potential cation channel subfamily V member 1 (TRPV1), widely expressed in microglia, influences their function by regulating the production of these immune-modulating molecules. To identify peptides...

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PMID: 40578722
DOI: 10.1016/j.phrs.2025.107837

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