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Identification of PPREs and PPRE associated genes in the human genome: insights into related kinases and disease implications

2 Oct 2024

Abstract excerpt

Introduction: "Peroxisome Proliferator-Activated Receptors" (PPARs) belong to the class of transcription factors (TF) identified as Nuclear Receptors (NR). Upon activation by peroxisome proliferators (PPs), PPARs modulate a diverse range of genes, consequently regulating intra-cellular lipid metabolism, glucose uptake, apoptosis, and cell proliferation. Subsequent to the heterodimerization of Retinoid X Receptors...

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PMID: 39434882
DOI: 10.3389/fimmu.2024.1457648

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