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Article

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550.

Molecular and cellular biology - 15 Jul 2016

Joo Min Sung, Kim Won Dong, Lee Ki Young, Kim Ji Hyun, Koo Ja Hyun, Kim Sang Geon

Abstract excerpt

Nrf2 (nuclear factor erythroid 2-related factor 2) is an antioxidant transcription factor. AMP-activated protein kinase (AMPK) functions as a central regulator of cell survival in response to stressful stimuli. Nrf2 should be coordinated with the cell survival pathway controlled by AMPK, but so far the mechanistic connections remain undefined. This study investigated the role of AMPK in Nrf2 trafficking and its...

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Identifiers

PMID: 27161318
DOI: 10.1128/MCB.00118-16
PMCID: PMC4936058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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