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Article

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

The EMBO journal - 23 Jan 2008

Hasegawa Mizuho, Fujimoto Yukari, Lucas Peter C, Nakano Hiroyasu, Fukase Koichi, Núñez Gabriel, Inohara Naohiro

Abstract excerpt

Nod1 and Nod2 are intracellular proteins that are involved in host recognition of specific bacterial molecules and are genetically associated with several inflammatory diseases. Nod1 and Nod2 stimulation activates NF-kappaB through RICK, a caspase-recruitment domain-containing kinase. However, the mechanism by which RICK activates NF-kappaB in response to Nod1 and Nod2 stimulation is unknown. Here we show that...

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Identifiers

PMID: 18079694
DOI: 10.1038/sj.emboj.7601962
PMCID: PMC2234345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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