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Article

Stochastic misfolding drives the emergence of distinct α-synuclein strains.

Neuron - 3 Jun 2026

So Raphaella W L, Frieg Benedikt, Camino José D, Situ Christopher, Metri Mark N, Silver Nicholas R G, Li Le Yao, Mao Alison, Stuart Erica, Schröder Gunnar F, Watts Joel C

Abstract excerpt

α-Synuclein conformational strains provide a potential explanation for the clinical and pathological differences among synucleinopathies such as Parkinson's disease and multiple system atrophy. However, how distinct α-synuclein strains arise remains unknown. Here, we observed conformational heterogeneity between individual preparations of α-synuclein pre-formed fibrils (PFFs) generated by polymerizing wild-type...

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Identifiers

PMID: 41763203
DOI: 10.1016/j.neuron.2026.01.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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