Article
Genome Gerrymandering: optimal division of the genome into regions with cancer type specific differences in mutation rates.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2020
Young Adamo, Chmura Jacob, Park Yoonsik, Morris Quaid, Atwal Gurnit
Abstract excerpt
The activity of mutational processes differs across the genome, and is influenced by chromatin state and spatial genome organization. At the scale of one megabase-pair (Mb), regional mutation density correlate strongly with chromatin features and mutation density at this scale can be used to accurately identify cancer type. Here, we explore the relationship between genomic region and mutation rate by developing...
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