TrackSigFreq: subclonal reconstructions based on mutation signatures and allele frequencies.

Abstract excerpt

Mutational signatures are patterns of mutation types, many of which are linked to known mutagenic processes. Signature activity represents the proportion of mutations a signature generates. In cancer, cells may gain advantageous phenotypes through mutation accumulation, causing rapid growth of that subpopulation within the tumour. The presence of many subclones can make cancers harder to treat and have other...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computational Biology
• Share to Gene Frequency