Article

TrackSig: reconstructing evolutionary trajectories of mutations in cancer

2018-02-05

Abstract excerpt

<h4>ABSTRACT</h4> We present a new method, TrackSig, to estimate the evolutionary trajectories of signatures of different somatic mutational processes from DNA sequencing data from a single, bulk tumour sample. TrackSig uses probability distributions over mutation types, called mutational signatures, to represent different mutational processes and detects the changes in the signature activity using an optimal seg...

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Literature Corpus work: 6beec1fe-f91a-5f3b-9d7b-2e8f783524b8
DOI: 10.1101/260471

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