Article
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome.
Nature medicine - 1 Dec 2019
Risal Sanjiv, Pei Yu, Lu Haojiang, Manti Maria, Fornes Romina, Pui Han-Pin, Zhao Zhiyi, Massart Julie, Ohlsson Claes, Lindgren Eva, Crisosto Nicolas, Maliqueo Manuel, Echiburú Barbara, Ladrón de Guevara Amanda, Sir-Petermann Teresa, Larsson Henrik, Rosenqvist Mina A, Cesta Carolyn E, Benrick Anna, Deng Qiaolin, Stener-Victorin Elisabet
Abstract excerpt
How obesity and elevated androgen levels in women with polycystic ovary syndrome (PCOS) affect their offspring is unclear. In a Swedish nationwide register-based cohort and a clinical case-control study from Chile, we found that daughters of mothers with PCOS were more likely to be diagnosed with PCOS. Furthermore, female mice (F0) with PCOS-like traits induced by late-gestation injection of dihydrotestosterone,...
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