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Developmental origins and transgenerational inheritance of polycystic ovary syndrome

17 Aug 2021

Abstract excerpt

BACKGROUND: There has been increasing awareness that polycystic ovary syndrome (PCOS) phenotypes may represent a mismatch between ancient genetically programmed metabolic and reproductive survival mechanisms and modern lifestyle practices. In-utero developmental programming of metabolic and endocrine pathways may play an important role in activating gene variants that predispose the offspring to develop PCOS when...

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PMID: 34403138
DOI: 10.1111/ajo.13420

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