Article
HLA-A*02:01 allele is associated with tanshinone-induced cutaneous drug reactions in Chinese population.
The pharmacogenomics journal - 1 Jun 2020
Zhu Qinyuan, Zhang Yanzhou, Xuan Jiekun, Yang Fanping, Du Binbin, Chen Sheng-An, Yan Sijia, Jiang Menglin, Zhu Huizhong, Xiong Hao, Luo Xiaoqun, Xing Qinghe
Abstract excerpt
Tanshinone, a widely used Chinese patent medicine, has been confirmed to have various kinds of pharmacological effects although frequently causing cutaneous adverse drug reactions (cADRs). We aim to identify whether human leukocyte antigen (HLA) class I alleles are associated with tanshinone-induced cADRs in Han Chinese. The association study including 18 patients with tanshinone-induced cADRs, 67...
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