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Article

HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.

Neurology - 6 Jun 2017

Shi Yi-Wu, Min Fu-Li, Zhou Dong, Qin Bin, Wang Juan, Hu Fa-Yun, Cheung Ying-Kit, Zhou Jin-Hua, Hu Xiang-Shu, Zhou Jue-Qian, Zhou Lie-Min, Zheng Zhong-Zheng, Pan Jie, He Na, Liu Zhi-Sheng, Hou Yun-Qi, Lim Kheng-Seang, Ou Yang-Mei, Hui-Ping Khor Amy, Ng Ching-Ching, Mao Bi-Jun, Liu Xiao-Rong, Li Bing-Mei, Kuan Yao-Yun, Yi Yong-Hong, He Xue-Lian, Deng Xiao-Yan, Su Tao, Kwan Patrick, Liao Wei-Ping

Abstract excerpt

OBJECTIVE: To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions. METHODS: A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced...

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Identifiers

PMID: 28476759
DOI: 10.1212/WNL.0000000000004008
PMCID: PMC5467955

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