Article
Intratumor heterogeneity and homologous recombination deficiency of high-grade serous ovarian cancer are associated with prognosis and molecular subtype and change in treatment course.
Gynecologic oncology - 1 Feb 2020
Takaya Hisamitsu, Nakai Hidekatsu, Sakai Kazuko, Nishio Kazuto, Murakami Kosuke, Mandai Masaki, Matsumura Noriomi
Abstract excerpt
OBJECTIVE: High-grade serous ovarian cancers (HGSOC) are genomically characterized by homologous recombination deficiency (HRD) and TP53 mutations, which lead to intratumor heterogeneity (ITH). This study aimed to reveal the relationship between HRD, ITH and prognosis and analyze their changes during treatment. METHODS: We obtained 573 SNP array and gene expression array data from The Cancer Genome Atlas. SNP...
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