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Article

PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression.

Cancer discovery - 1 May 2016

Xiao Xiao, Lao Xiang-Ming, Chen Min-Min, Liu Rui-Xian, Wei Yuan, Ouyang Fang-Zhu, Chen Dong-Ping, Zhao Xiao-Yu, Zhao Qiyi, Li Xue-Feng, Liu Chuan-Lu, Zheng Limin, Kuang Dong-Ming

Abstract excerpt

UNLABELLED: B cells often constitute abundant cellular components in human tumors. Regulatory B cells that are functionally defined by their ability to produce IL10 downregulate inflammation and control T-cell immunity. Here, we identified a protumorigenic subset of B cells that constitutively expressed higher levels of programmed cell death-1 (PD-1) and constituted ∼10% of all B cells in advanced-stage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-bcl-6

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Source

Identifiers

PMID: 26928313
DOI: 10.1158/2159-8290.CD-15-1408

Genes

BCL6
TLR4
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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