Article
Tumoral PD-1hiCD8+ T cells are partially exhausted and predict favorable outcome in triple-negative breast cancer.
Clinical science (London, England : 1979) - 17 Apr 2020
Guo Liang, Cao Chunmei, Goswami Shyamal, Huang Xiaoyan, Ma Linxiaoxi, Guo Yicheng, Yang Benlong, Li Teng, Chi Yayun, Zhang Xiaoming, Wu Jiong
Abstract excerpt
Tumor-infiltrating PD-1hi dysfunctional CD8+ T cells have been identified in several tumors but largely unexplored in breast cancer (BC). Here we aimed to extensively explore PD-1hiCD8+ T cells in BC, focusing on the triple-negative BC (TNBC) subtype. Flow cytometry was used to study the phenotypes and functions of CD8+ T-cell subsets in peripheral blood and surgical specimens from treatment-naive BC patients....
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