Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.

doi:10.1038/ng.2971

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Article

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.

Nature genetics - 1 Jul 2014

Uslu Veli Vural, Petretich Massimo, Ruf Sandra, Langenfeld Katja, Fonseca Nuno A, Marioni John C, Spitz François

Abstract excerpt

Cleft lip with or without cleft palate (CL/P) is one of the most common congenital malformations observed in humans, with 1 occurrence in every 500-1,000 births. A 640-kb noncoding interval at 8q24 has been associated with increased risk of non-syndromic CL/P in humans, but the genes and pathways involved in this genetic susceptibility have remained elusive. Using a large series of rearrangements engineered over...

Topics

Animals
Cell Proliferation
Chromatin Immunoprecipitation
Cleft Lip
Cleft Palate
Embryo, Mammalian
Enhancer Elements, Genetic
Face
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
In Situ Hybridization

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Transgenic

Morphogenesis

Source

Open in PubMed

Identifiers

PMID: 24859337
DOI: 10.1038/ng.2971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.