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Next-generation sequencing-based evaluation of the actionable landscape of genomic alterations in solid tumors: the "MOZART" prospective observational study.

The oncologist - 17 Jan 2025

Schettini Francesco, Sirico Marianna, Loddo Marco, Williams Gareth H, Hardisty Keeda-Marie, Scorer Paul, Thatcher Robert, Rivera Pablo, Milani Manuela, Strina Carla, Ferrero Giuseppina, Ungari Marco, Bottin Cristina, Zanconati Fabrizio, de Manzini Nicolò, Aguggini Sergio, Tancredi Richard, Fiorio Elena, Fioravanti Antonio, Scaltriti Maurizio, Generali Daniele

Abstract excerpt

BACKGROUND: The identification of the most appropriate targeted therapies for advanced cancers is challenging. We performed a molecular profiling of metastatic solid tumors utilizing a comprehensive next-generation sequencing (NGS) assay to determine genomic alterations' type, frequency, actionability, and potential correlations with PD-L1 expression. METHODS: A total of 304 adult patients with heavily pretreated...

Topics

Humans
High-Throughput Nucleotide Sequencing
Female
Neoplasms
Male
Middle Aged
Prospective Studies
Aged
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Genomics

Biomarkers, Tumor

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Open in PubMed Open full text

Identifiers

PMID: 39177668
DOI: 10.1093/oncolo/oyae206
PMCID: PMC11783315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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