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Article

The spectrum of MAPK-ERK pathway genomic alterations in gynecologic malignancies: Opportunities for novel therapeutic approaches.

Gynecologic oncology - 1 Oct 2023

Nasioudis Dimitrios, Fernandez Marta Llaurado, Wong Nelson, Powell Daniel J, Mills Gordon B, Westin Shannon, Fader Amanda N, Carey Mark S, Simpkins Fiona

Abstract excerpt

OBJECTIVE: To investigate the incidence of MAPK/ERK pathway genomic alterations among patients with gynecologic malignancies. METHODS: We accessed the American Association of Cancer Research Genomics Evidence of Neoplasia Information Exchange publicly available dataset (v13.0). Patients with malignant tumors of the ovary, uterus, and cervix were identified. Following stratification by tumor site and histology, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 37657193
DOI: 10.1016/j.ygyno.2023.08.007

Genes

BRAF
KRAS
NF1
NRAS
ARAF
HRAS
MAP2K1
PTPN11
RAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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