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Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers

10 Oct 2021

Abstract excerpt

The mitogen-activated protein kinase (MAPK) pathway, consisting of the Ras-Raf-MEK-ERK signaling cascade, regulates genes that control cellular development, differentiation, proliferation, and apoptosis. Within the cascade, multiple isoforms of Ras and Raf each display differences in functionality, efficiency, and, critically, oncogenic potential. According to the NCI, over 30% of all human cancers are driven by...

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PMID: 34680208
DOI: 10.3390/cancers13205059

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