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Article

Antimutagenic action of methionine in Chinese hamster fibroblasts: an opposite of methionine mutagenicity.

Anticancer research - 1 Jan 2000

Hill M, Hillova J, Mariage-Samson R, Brada Z

Abstract excerpt

Serially propagated fibroblast clones were treated with 25-mM methionine and a thioguanine resistance assay was performed at each passage to measure mutagenesis at the HGPRT locus. The spontaneous frequency of thioguanine resistant mutants before treatment was less than 5 X 10(-6) in four clones and 22 X 10(-6) in one clone. These values dropped 10- to 100-fold and remained so until the methionine was withdrawn,...

Topics

Animals
Blotting, Southern
Cell Line
Clone Cells
Cricetinae
Cricetulus
Drug Resistance
Fibroblasts
Hypoxanthine Phosphoribosyltransferase
Methionine
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Thioguanine

Source

Identifiers

PMID: 3178160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3178160-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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