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Antimutagenic action of methionine in Chinese hamster fibroblasts: an opposite of methionine mutagenicity.

Anticancer research - 1 Jan 2000

Hill M, Hillova J, Mariage-Samson R, Brada Z

Abstract excerpt

Serially propagated fibroblast clones were treated with 25-mM methionine and a thioguanine resistance assay was performed at each passage to measure mutagenesis at the HGPRT locus. The spontaneous frequency of thioguanine resistant mutants before treatment was less than 5 X 10(-6) in four clones and 22 X 10(-6) in one clone. These values dropped 10- to 100-fold and remained so until the methionine was withdrawn,...

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PMID: 3178160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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