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Article

Distribution of PTPN22 polymorphisms in SLE from western Mexico: correlation with mRNA expression and disease activity.

Clinical and experimental medicine - 1 Aug 2016

Machado-Contreras Jesús René, Muñoz-Valle José Francisco, Cruz Alvaro, Salazar-Camarena Diana Celeste, Marín-Rosales Miguel, Palafox-Sánchez Claudia Azucena

Abstract excerpt

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune inflammatory disease characterized by loss of self-tolerance with hyperactivation of autoreactive T and B cells. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) encodes for lymphoid-specific phosphatase (Lyp), which is a key negative regulator of T lymphocyte activation. The aim of this study was to evaluate the genetic contribution of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Identifiers

PMID: 26013387
DOI: 10.1007/s10238-015-0359-0

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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