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Article

Effects of SLCO1B1 on elimination and toxicities of high-dose methotrexate in pediatric acute lymphoblastic leukemia.

Pharmacogenomics - 1 Oct 2022

Yang Fei-Fei, Xue Tian-Lin, Gao Chao, Wu Ying, Lin Wei, Li Jun, Zhang Rui-Dong, Zheng Hu-Yong, Liu Shu-Guang

Abstract excerpt

Aim: To evaluate the association between SLCO1B1 polymorphisms and elimination/toxicities of high-dose methotrexate (MTX). Methods: SLCO1B1 rs11045879 and rs4149056 polymorphisms were retrospectively genotyped in 301 children with newly diagnosed acute lymphoblastic leukemia. MTX concentration, doses of leucovorin rescue and toxicities were recorded. Results: SLCO1B1 rs11045879C carriers (CC + CT) had higher...

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Identifiers

PMID: 36193736
DOI: 10.2217/pgs-2022-0098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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