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Article

SLCO1B1 *15 allele is associated with methotrexate-induced nausea in pediatric patients with inflammatory bowel disease.

Clinical and translational science - 1 Jan 2022

Mehta Rishi S, Taylor Zachary L, Martin Lisa J, Rosen Michael J, Ramsey Laura B

Abstract excerpt

Low-dose methotrexate (MTX) is an immunosuppressant used to treat inflammatory bowel disease (IBD). SLCO1B1 genetic variation has been associated with delayed MTX clearance and increased toxicity. The purpose of this study was to evaluate the association between SLCO1B1 genetic variation and MTX-induced nausea in children with IBD. We performed a single center retrospective chart analysis of 278 patients who were...

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Identifiers

PMID: 34423897
DOI: 10.1111/cts.13130
PMCID: PMC8742639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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