Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile.

doi:10.1126/scitranslmed.aax7350

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Article

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile.

Science translational medicine - 27 Nov 2019

Garcia-Broncano Pilar, Maddali Shivaali, Einkauf Kevin B, Jiang Chenyang, Gao Ce, Chevalier Joshua, Chowdhury Fatema Z, Maswabi Kenneth, Ajibola Gbolahan, Moyo Sikhulile, Mohammed Terence, Ncube Thabani, Makhema Joseph, Jean-Philippe Patrick, Yu Xu G, Powis Kathleen M, Lockman Shahin, Kuritzkes Daniel R, Shapiro Roger, Lichterfeld Mathias

Abstract excerpt

Neonatal HIV-1 infection is associated with rapidly progressive and frequently fatal immune deficiency if left untreated. Immediate institution of antiretroviral therapy (ART), ideally within hours after birth, may restrict irreversible damage to the developing neonatal immune system and possibly provide opportunities for facilitating drug-free viral control during subsequent treatment interruptions. However, the...

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PMID: 31776292
DOI: 10.1126/scitranslmed.aax7350
PMCID: PMC8397898

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Source receipt: pubmed, retrieved 6 Sept 2026.

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