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Article

Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants

14 May 2024

Abstract excerpt

Abstract While preventing vertical HIV transmission has been very successful, HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections compared to HIV-unexposed and uninfected infants (iHUU). Here we present a longitudinal multimodal analysis of infant immune ontogeny that highlights the impact of HIV/ARV exposure. Using mass cytometry, we show alterations in T cell memory differentiation...

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PMID: 38744812
DOI: 10.1038/s41467-024-47955-5

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