Article
Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1.
Scientific reports - 24 Oct 2014
Bunders Madeleine J, van Hamme John L, Jansen Machiel H, Boer Kees, Kootstra Neeltje A, Kuijpers Taco W
Abstract excerpt
Absolute numbers of lymphocytes are decreased in uninfected infants born to HIV-1-infected women (HIV-1-exposed). Although the exact mechanism is unknown, fetal exposure to maternal HIV-1-infection could prime the immune system and affect T cell trafficking. We compared the expression of chemokine receptors on cord blood CD4(+) T cells from HIV-1-exposed children and healthy controls. At baseline CD4(+) T cells...
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