Article
Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection.
PloS one - 1 Jan 2017
Rainwater-Lovett Kaitlin, Ziemniak Carrie, Watson Douglas, Luzuriaga Katherine, Siberry George, Petru Ann, Chen YaHui, Uprety Priyanka, McManus Margaret, Ho Ya-Chi, Lamers Susanna L, Persaud Deborah
Abstract excerpt
The latent reservoir is a major barrier to HIV eradication. Reservoir size is emerging as an important biomarker to assess the likelihood of HIV remission in the absence of antiretroviral therapy (ART) and may be reduced by earlier initiation of ART that restricts HIV spread into CD4+ T cells. Reservoir size is traditionally measured with a quantitative viral outgrowth assay (QVOA) that induces...
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