Article

Early Treatment Regimens Achieve Sustained Virologic Remission in Infant Macaques Infected with SIV at Birth

2022-02-14

Abstract excerpt

<title>Abstract</title> <p>Early antiretroviral therapy (ART) in HIV-infected infants generally fails to achieve a sustained state of ART-free virologic remission, leading to rapid viral rebound, even after years of analytical treatment interruption. Our studies showed that in contrast to adults, skewing of viral integration was observed in neonatal macaques intravenously exposed to SIV at birth. Further, one mon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e037d9c-ebb1-5133-ab85-d2c563e736e4
DOI: 10.21203/rs.3.rs-1319119/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Treatment Regimens Achieve Sustained Virologic Remission in Infant Macaques Infected with SIV at BirthDOI 10.21203/rs.3.rs-1319119/v1Read

Early Treatment with Integrase Inhibitor Achieves a Functional Cure for Pediatric SIV InfectionSemantic proximity Read

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile.Semantic proximity Read

Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected InfantsSemantic proximity Read

Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure.Semantic proximity Read

Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants.Semantic proximity Read

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus MacaquesSemantic proximity Read

Long-term Virologic Suppression Despite Presence of Resistance-associated Mutations Among Perinatally HIV-infected Youth.Semantic proximity Read

Immunology of pediatric HIV infectionSemantic proximity Read

Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection.Semantic proximity Read

Assessing the impact of autologous neutralizing antibodies on viral rebound in postnatally SHIV-infected ART-treated infant rhesus macaquesSemantic proximity Read

HIV ‐1 DNA decay is faster in children who initiate ART shortly after birth than laterSemantic proximity Read

Comparative Analysis of Within-Host Dynamics of Acute Infection and Viral Rebound Dynamics in Postnatally SHIV-Infected ART-Treated Infant Rhesus MacaquesSemantic proximity Read