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Article

Patterns of pretreatment drug resistance mutations of very early diagnosed and treated infants in Botswana.

AIDS (London, England) - 1 Dec 2021

Moraka Natasha Onalenna, Garcia-Broncano Pilar, Hu Zixin, Ajibola Gbolahan, Bareng Ontlametse T, Pretorius-Holme Molly, Maswabi Kenneth, Maphorisa Comfort, Mohammed Terence, Gaseitsiwe Simani, VanZyl Gert U, Kuritzkes Daniel R, Lichterfeld Mathias, Moyo Sikhulile, Shapiro Roger L

Abstract excerpt

OBJECTIVE: To describe the occurrence of HIV drug resistance mutations (DRMs) in both intact and defective HIV-1 cell-associated DNA (HIV-1 CAD) among early-treated infants. DESIGN: The Botswana EIT Study (ClinicalTrials.gov NCT02369406) initiated antiretroviral therapy (ART) in the first week of life and evaluated HIV-1 in plasma and peripheral blood mononuclear cells (PBMCs). METHODOLOGY: We analyzed 257...

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Identifiers

PMID: 34324451
DOI: 10.1097/QAD.0000000000003041
PMCID: PMC8631156

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