Article

Escalating protein supersaturation underlies inclusion formation in muscle proteinopathies

2019-09-12

Abstract excerpt

Abundant, aggregation prone or “supersaturated” proteins are a feature of neurodegeneration. Whether the principle of supersaturation can similarly explain the widespread aggregation that occurs in non-neuronal protein conformational disorders and underlies pathogenic protein aggregate formation is not established. To test this prediction we analyzed proteomic datasets of biopsies from genetic and acquired protein...

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Literature Corpus work: 357bb8ee-11e8-53d6-8f57-5b367e8e09fc
DOI: 10.1101/762245

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