A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation

Abstract excerpt

It is well-established that widespread transcriptional changes accompany the onset and progression of Alzheimer's disease. Because of the multifactorial nature of this neurodegenerative disorder and its complex relationship with aging, however, it remains unclear whether such changes are the result of nonspecific dysregulation and multisystem failure or instead are part of a coordinated response to cellular...

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