Article
Characterization of Single Gene Copy Number Variants in Schizophrenia.
Biological psychiatry - 15 Apr 2020
Szatkiewicz Jin P, Fromer Menachem, Nonneman Randal J, Ancalade NaEshia, Johnson Jessica S, Stahl Eli A, Rees Elliott, Bergen Sarah E, Hultman Christina M, Kirov George, O'Donovan Michael, Owen Michael, Holmans Peter, Sklar Pamela, Sullivan Patrick F, Purcell Shaun M, Crowley James J, Ruderfer Douglas M
Abstract excerpt
BACKGROUND: Genetic studies of schizophrenia have implicated numerous risk loci including several copy number variants (CNVs) of large effect and hundreds of loci of small effect. In only a few cases has a specific gene been clearly identified. Rare CNVs affecting a single gene offer a potential avenue to discovering schizophrenia risk genes. METHODS: CNVs were generated from exome sequencing of 4913...
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