Article
Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.
Human molecular genetics - 15 Apr 2009
Kirov George, Grozeva Detelina, Norton Nadine, Ivanov Dobril, Mantripragada Kiran K, Holmans Peter, Craddock Nick, Owen Michael J, O'Donovan Michael C
Abstract excerpt
We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped using the Affymetrix GeneChip 500K Mapping Array. Large CNVs >1 Mb were 2.26 times more common in cases (P = 0.00027), with the effect coming mostly from deletions (odds ratio, OR = 4.53, P = 0.00013) although duplications were also more common (OR = 1.71, P = 0.04)....
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