Article
Detecting large copy number variants using exome genotyping arrays in a large Swedish schizophrenia sample.
Molecular psychiatry - 1 Nov 2013
Szatkiewicz J P, Neale B M, O'Dushlaine C, Fromer M, Goldstein J I, Moran J L, Chambert K, Kähler A, Magnusson P K E, Hultman C M, Sklar P, Purcell S, McCarroll S A, Sullivan P F
Abstract excerpt
Although copy number variants (CNVs) are important in genomic medicine, CNVs have not been systematically assessed for many complex traits. Several large rare CNVs increase risk for schizophrenia (SCZ) and autism and often demonstrate pleiotropic effects; however, their frequencies in the general population and other complex traits are unknown. Genotyping large numbers of samples is essential for progress. Large...
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