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Article

Double hits in schizophrenia.

Human molecular genetics - 1 Aug 2018

Vorstman Jacob A S, Olde Loohuis Loes M, Kahn René S, Ophoff Roel A

Abstract excerpt

The co-occurrence of a copy number variant (CNV) and a functional variant on the other allele may be a relevant genetic mechanism in schizophrenia. We hypothesized that the cumulative burden of such double hits-in particular those composed of a deletion and a coding single-nucleotide variation (SNV)-is increased in patients with schizophrenia. We combined CNV data with coding variants data in 795 patients with...

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Identifiers

PMID: 29767709
DOI: 10.1093/hmg/ddy175
PMCID: PMC6049008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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