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Article

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Gastroenterology - 1 Nov 2014

Hermann Patrick C, Sancho Patricia, Cañamero Marta, Martinelli Paola, Madriles Francesc, Michl Patrick, Gress Thomas, de Pascual Ricardo, Gandia Luis, Guerra Carmen, Barbacid Mariano, Wagner Martin, Vieira Catarina R, Aicher Alexandra, Real Francisco X, Sainz Bruno, Heeschen Christopher

Abstract excerpt

BACKGROUND & AIMS: Although smoking is a leading risk factor for pancreatic ductal adenocarcinoma (PDAC), little is known about the mechanisms by which smoking promotes initiation or progression of PDAC. METHODS: We studied the effects of nicotine administration on pancreatic cancer development in Kras(+/LSLG12Vgeo);Elas-tTA/tetO-Cre (Ela-KRAS) mice, Kras(+/LSLG12D);Trp53+/LSLR172H;Pdx-1-Cre (KPC) mice (which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25127677
DOI: 10.1053/j.gastro.2014.08.002

Genes

KRAS
GATA6
MYC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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