Article
Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.
Journal of autoimmunity - 1 Feb 2020
Schurman Shepherd H, O'Hanlon Terrance P, McGrath John A, Gruzdev Artiom, Bektas Arsun, Xu Hong, Garantziotis Stavros, Zeldin Darryl C, Miller Frederick W
Abstract excerpt
BACKGROUND: Because immune responses are sensitive to environmental changes that drive selection of genetic variants, we hypothesized that polymorphisms of some xenobiotic response and immune response genes may be associated with specific types of immune-mediated diseases (IMD), while others may be associated with IMD as a larger category regardless of specific phenotype or ethnicity. OBJECTIVE: To examine...
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