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Genetic variation in CYP1A1 and AHRR genes increase the risk of systemic lupus erythematosus and exacerbate disease severity in smoker patients.

Journal of biochemical and molecular toxicology - 1 Dec 2021

Saghaeian Jazi Marie, Mohammadi Saeed, Zare Ebrahimabad Mojtaba, Sedighi Sima, Abdolahi Nafiseh, Tabarraei Alijan, Yazdani Yaghoub

Abstract excerpt

BACKGROUND: Genetic variations of aryl hydrocarbon receptor (AHR) pathway genes could influence the imbalanced immune response to xenobiotics. Therefore, we aimed to investigate the polymorphism of AHR pathway genes in systemic lupus erythematosus (SLE) patients in association with smoking. METHODS: Genomic DNA from patients (N = 107) and controls (N = 105) of a population from northeast of Iran was used for...

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Basic Helix-Loop-Helix Transcription Factors
Cigarette Smoking
Cytochrome P-450 CYP1A1
Gene-Environment Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lupus Erythematosus, Systemic

Repressor Proteins

Severity of Illness Index

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PMID: 34580959
DOI: 10.1002/jbt.22916

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