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Article

The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.

Frontiers in immunology - 1 Jan 2022

Zhang Tian-Ping, Li Rui, Li Hong-Miao, Xiang Nan, Tan Zhen, Wang Guo-Sheng, Li Xiao-Mei

Abstract excerpt

The aryl hydrocarbon receptor (AHR) signaling pathway participates in immune regulation of multiple autoimmune diseases, including rheumatoid arthritis (RA). We conducted this study to investigate the association of AHR signaling pathway genes (AHR, ARNT, AHRR) single nucleotide polymorphisms (SNPs), as well as their methylation levels, with RA susceptibility. Nine SNPs (AHR gene rs2066853, rs2158041, rs2282885,...

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Share to Arthritis, Rheumatoid
Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Basic Helix-Loop-Helix Transcription Factors
Share to Methylation
Share to Polymorphism, Single Nucleotide
Share to Receptors, Aryl Hydrocarbon
Share to Repressor Proteins
Share to Signal Transduction

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Identifiers

PMID: 35309329
DOI: 10.3389/fimmu.2022.823863
PMCID: PMC8924038

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