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Article

Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases.

Journal of translational medicine - 29 Apr 2024

Wen Jie, Zhang Jingwei, Zhang Hao, Zhang Nan, Lei Ruoyan, Deng Yujia, Cheng Quan, Li He, Luo Peng

Abstract excerpt

BACKGROUND: Epidemiological evidence links a close correlation between long-term exposure to air pollutants and autoimmune diseases, while the causality remained unknown. METHODS: Two-sample Mendelian randomization (TSMR) was used to investigate the role of PM10, PM2.5, NO2, and NOX (N = 423,796-456,380) in 15 autoimmune diseases (N = 14,890-314,995) using data from large European GWASs including UKB, FINNGEN,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38685026
DOI: 10.1186/s12967-024-04928-y
PMCID: PMC11057084

Genes

POR
BRD2
HSPA1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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