Article
Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2015
Heidel Florian H, Arreba-Tutusaus Patricia, Armstrong Scott A, Fischer Thomas
Abstract excerpt
Acute myelogenous leukemia stem cells (AML-LSC) give rise to the leukemic bulk population and maintain disease. Relapse can arise from residual LSCs that have distinct sensitivity and dependencies when compared with the AML bulk. AML-LSCs are driven by genetic and epigenomic changes, and these alterations influence prognosis and clonal selection. Therapies targeting these molecular aberrations have been developed...
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