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Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease

25 Feb 2026

Abstract excerpt

Vitamins are essential metabolites that must be obtained from external sources. In modern times, they have become widely available, leading to their ad hoc consumption. We developed a nutritional genomics framework to systematically identify monogenic diseases responsive to micronutrient modulation. Genome-wide CRISPR screens under varying vitamin B2 and B3 levels revealed dozens of candidate disease genes...

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PMID: 41747729
DOI: 10.1016/j.cell.2026.01.022

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