Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease

25 Feb 2026

Abstract excerpt

Vitamins are essential metabolites that must be obtained from external sources. In modern times, they have become widely available, leading to their ad hoc consumption. We developed a nutritional genomics framework to systematically identify monogenic diseases responsive to micronutrient modulation. Genome-wide CRISPR screens under varying vitamin B2 and B3 levels revealed dozens of candidate disease genes...

Topics

Join the communities discussing this publication.

Folate and B Vitamins Research
Nutrition, Genetics, and Disease
Vitamin D Research Studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41747729
DOI: 10.1016/j.cell.2026.01.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD diseasePMID 41747729Read ↗

A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.Semantic proximity Read ↗

Unveiling Immune System Perturbations in Early Development Through Zebrafish Models of NADHX Repair Deficiency.Semantic proximity Read ↗

Nicotinamide Adenine Dinucleotide Deficiency and Its Impact on Mammalian Development.Semantic proximity Read ↗

NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood.Semantic proximity Read ↗

Nuclear NAD <sup>+</sup> -biosynthetic enzyme NMNAT1 facilitates survival of developing retinal neuronsSemantic proximity Read ↗

NAXD Deficiency: Heterogeneous Phenotypes and Positive Response to Niacin Treatment.Semantic proximity Read ↗

STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the <i>Nan</i> (EKLF/E339D) mouse model of neonatal anemiaSemantic proximity Read ↗

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.Semantic proximity Read ↗

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.Semantic proximity Read ↗

Mouse models of <i>NADK2</i> deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiologySemantic proximity Read ↗

Bi-allelic Mutations in NADSYN1 Cause Multiple Organ Defects and Expand the Genotypic Spectrum of Congenital NAD Deficiency Disorders.Semantic proximity Read ↗

NAD(P)HX dehydratase protein-truncating mutations are associated with neurodevelopmental disorder exacerbated by acute illnessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.