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Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter

4 Aug 2020

Abstract excerpt

Significance The murine protein Slc11a1 (SLC11A1 in humans) hinders replication of invading microbes by provoking Mg 2+ limitation in host tissues. To withstand Mg 2+ limitation and to promote survival in Slc11a1 + / + macrophages, the intracellular pathogen Salmonella enterica serovar Typhimurium requires MgtB, one of its three Mg 2+ transporters and the only one absent from commensal Escherichia coli . Although...

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PMID: 32753384
DOI: 10.1073/pnas.2006116117

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