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A Salmonella subset exploits erythrophagocytosis to subvert SLC11A1-imposed iron deprivation

1 May 2025

Abstract excerpt

Solute carrier family 11 member 1 (SLC11A1) is critical for host resistance to diverse intracellular pathogens. During infection, SLC11A1 limits Salmonella's access to iron, zinc, and magnesium, but only magnesium deprivation significantly impairs Salmonella replication. To understand the unexpected minor impact of iron, we determined Salmonella's iron access in infected SLC11A1-deficient and normal mice. Using...

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PMID: 40373749
DOI: 10.1016/j.chom.2025.04.013

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