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Genome-wide fitness analysis of Salmonella enterica reveals aroA mutants are attenuated due to iron restriction in vitro.

mBio - 16 Oct 2024

Rooke Jessica L, Goodall Emily C A, Pullela Karthik, Da Costa Rochelle, Martinelli Nicole, Smith Chelsie, Mora Maria, Cunningham Adam F, Henderson Ian R

Abstract excerpt

Salmonella enterica is a globally disseminated pathogen that is the cause of over 100 million infections per year. The resulting diseases are dependent upon host susceptibility and the infecting serovar. As S. enterica serovar Typhimurium induces a typhoid-like disease in mice, this model has been used extensively to illuminate various aspects of Salmonella infection and host responses. Due to the severity of...

Topics

Iron
Genome, Bacterial
Salmonella typhimurium
Mice
Animals
Mutation
Salmonella enterica
Genetic Fitness
Bacterial Proteins
Salmonella Infections
DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virulence

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Identifiers

PMID: 39287440
DOI: 10.1128/mbio.03319-23
PMCID: PMC11481492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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