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Article

Activation of the Unfolded Protein Response and Proteostasis Disturbance in Parkinsonism-Dementia of Guam.

Journal of neuropathology and experimental neurology - 1 Jan 2020

Verheijen Bert M, Lussier Celina, Müller-Hübers Cora, Garruto Ralph M, Oyanagi Kiyomitsu, Braun Ralf J, van Leeuwen Fred W

Abstract excerpt

Guam parkinsonism-dementia (G-PD) is a progressive and fatal neurodegenerative disorder among the native inhabitants of the Mariana Islands that manifests clinically with parkinsonism as well as dementia. Neuropathologically, G-PD is characterized by abundant neurofibrillary tangles composed of hyperphosphorylated tau, marked deposition of transactive response DNA-binding protein 43 kDa (TDP-43), and neuronal...

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PMID: 31750913
DOI: 10.1093/jnen/nlz110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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