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Mechanism of neurodegenerative disease: role of the ubiquitin proteasome system

1 Jan 2004

Abstract excerpt

Many neurodegenerative disorders such as Alzheimer's disease (AD) Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are characterized by neuronal damage that may be caused by toxic, abnormal, aggregation-prone proteins. The purpose of this review is threefold: 1) to provide the reader with an overview of the genes involved in the abnormal processing and accumulation of...

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PMID: 15224658
DOI: 10.1080/07853890410031948

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