Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.

The Journal of pathology - 1 Apr 2012

Nijholt Diana A T, van Haastert Elise S, Rozemuller Annemieke J M, Scheper Wiep, Hoozemans Jeroen J M

Abstract excerpt

The unfolded protein response (UPR) is a stress response activated upon disturbed homeostasis in the endoplasmic reticulum (ER). Previously, we reported that the activation of the UPR closely correlates with the presence of phosphorylated tau (p-tau) in Alzheimer's disease (AD). As well as increased presence of intracellular p-tau, AD brains are characterized by extracellular deposits of β amyloid (Aβ). Recent in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autopsy
Share to eIF-2 Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoribonucleases

Share to Hippocampus

Share to tau Proteins

Share to Tauopathies

Share to Unfolded Protein Response

Share to Up-Regulation

Source

Identifiers

PMID: 22102449
DOI: 10.1002/path.3969

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.PMID 22102449Read ↗

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying NeurodegenerationSemantic proximity Read ↗

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease.Semantic proximity Read ↗

Unfolded protein response activation in C9orf72 frontotemporal dementia is associated with dipeptide pathology and granulovacuolar degeneration in granule cellsSemantic proximity Read ↗

Activation of the Unfolded Protein Response and Proteostasis Disturbance in Parkinsonism-Dementia of Guam.Semantic proximity Read ↗

Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative DiseasesSemantic proximity Read ↗

Current Advances on Different Kinases Involved in Tau Phosphorylation, and Implications in Alzheimers Disease and TauopathiesSemantic proximity Read ↗

Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.Semantic proximity Read ↗

Neurodegeneration Risk Factor, <i>EIF2AK3</i> ( <i>PERK</i> ), Influences Tau Protein AggregationSemantic proximity Read ↗

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasisSemantic proximity Read ↗

Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative diseaseSemantic proximity Read ↗

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.Semantic proximity Read ↗

[Involvement of unfolded protein responses in neurodegeneration].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.